

This act puts Frank on alert, and he locks down the city. Once they rescue Wayne, the group sets fire to the old riverboat that functions as a headquarters for Frank's people. Frank's gang imprisoned many people out in the Louisiana wetlands, to be shipped off to work in DeVitt's mines. They're rescued by a Voodoo practitioner called Isabelle Moreau, who joins them in order to find her partner, Marshal Wayne. The group eventually gets captured on their way to New Orleans, where Frank is located. They paid Doc McCoy to help them in defense which becomes eventually successful, though Kate's uncle Ian perishes in the battle. The newly met pair promptly escape the mansion and head for the O'Hara Ranch to defend it from the attacking DeVitt company men. In the escalating altercation, Kate shoots the mayor as Cooper walks in, seeking Frank. In the meantime, the mayor's prospective bride, Kate O'Hara, who has been using the marriage as a chance to get access to mayor's office to retrieve the lost deeds of her family ranch, finds out that the mayor has already sold her family's ranch to the Devitt Company. Once at Flagstone, Cooper learns from his friend Hector Mendoza that Frank is at the mansion of the soon-to-be-married local mayor. Along the way, Cooper meets Doctor McCoy, who was hired by the DeVitt Company, a wealthy corporation, to defend the train Cooper was taking on his way to the town of Flagstone.

The story follows him as he pursues Frank, a notorious bandit leader responsible for the death of John's father, James Cooper. The story is set in 1875 as a prequel to Desperados: Wanted Dead or Alive, the first game in the series, and explores the origin of the series' protagonist John Cooper. 3.2 Chapter II: The Marshal & The Witch.
